TECOS-Analyse

Pancreatic Safety of Sitagliptin in the TECOS Study

OBJECTIVE We evaluated the incidence of acute pancreatitis and pancreatic cancer in patients with type 2 diabetes and cardiovascular disease who were treated with sitagliptin, a dipeptidyl peptidase-4 inhibitor (DPP-4i). RESEARCH DESIGN AND METHODS In the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS) study, a cardiovascular safety study of sitagliptin, all suspected cases ...

Analyse numérique

Impact-Analyse für AspectJ - Eine kritische Analyse mit werkzeuggestütztem Ansatz

duced allows to inspect software systems on architecture level described in ROOM notation. Explicit usage of domain knowledge in the development of concepts, methods, and tools guarantees suitability and user acceptance. The analysis of multi-language software systems is possible due to the realization of a seamlessly integrated yet open, modular, extensible, and flexible reengineering system.

Analyse Power Consumption by Mobile Applications Using Fuzzy Clustering Approach

With the advancements in mobile technology and its utilization in every facet of life, mobile popularity has enhanced exponentially. The biggest constraint in the utility of mobile devices is that they are powered with batteries. Optimizing mobile’s size and weight is always the choice of designer, which led limited size and capacity of battery used in mobile phone. In this paper analysis of th...

Gliptins and Cardiovascular Outcomes: A Comparative and Critical Analysis after TECOS

The issue related to macrovascular outcomes and intensive glycemic control was hotly debated after the publication of landmark trials like ACCORD, ADVANCE, and VADT. The only benefits seem to come from intervening early on in the disease process as indicated by the 10-year UKPDS follow-up. To complicate matters USFDA made it mandatory for modern drugs to conduct cardiovascular safety trials in ...